The WCC Note

Your Weekly Guide to Harmonizing Clinical Trial Imaging

Posts Tagged ‘Mammography’

Radiology: The Basic Modalities
Ultrasound Mammography – Vol. 1, Number 6

Wednesday, October 31st, 2007

How it works. As discussed in a recent issue of The WCC Note (Volume 1, Number 3), an ultrasound machine uses sound waves to differentiate the types of tissues within the breast.  Because of the lack of radiation and its ability to see structures in “real time,” ultrasound is a good tool for the evaluation of the breast in certain situations.

However, ultrasound is not a good test for screening the breasts – that is, if a healthy woman without any symptoms gets an ultrasound scan, it can be extremely difficult to find a small cancer.  In addition, ultrasound is a poor test in patients with very large or dense breasts, because the sound waves cannot pass through the excess fatty tissue.  Breast ultrasound is useful in evaluating masses that have already been seen on a mammogram or felt by a patient.

Evaluating a Known Mass
If a woman feels a lump in her breast but it can’t be seen on a mammogram, or if a mass is seen on a mammogram but it is uncertain whether it is benign or malignant (which is very common), an ultrasound can be done to evaluate it further.  In these situations, the ultrasound operator already knows the location of the mass and can do a dedicated ultrasound examination of that area to characterize it better.  This is useful because an ultrasound can show that a mass is definitely a benign growth, which would prevent the woman form having to get a biopsy.

The most common benign mass that can be confirmed on an ultrasound is a simple cyst – a small collection of fluid (see Figure 1).  Ultrasound is extremely accurate in identifying simple cysts, because it depends on the transmission of sound waves and simple fluid transmits sound waves very well.  As a result, a simple cyst will appear completely black on ultrasound; this black appearance is “anechoic,” meaning that the fluid produces no echoes, or does not make any of the sound waves bounce back, because the sound waves are transmitted through it so easily.

BIOPSIES: ULTRASOUND, STEREOTACTIC, AND MRI

A biopsy is a procedure where a small piece of a mass that is suspected to be cancer is removed from a patient using a needle, so that it can be examined under a microscope to see what it is.  Ultrasound is also very useful in helping physicians find the right place to insert the needle during a biopsy.  Because it is a “real-time” imaging exam, the images seen on the screen show exactly what is happening at the time the transducer is on the patient see Figure 2).  Thus, a physician can watch in real time as the needle goes through the patient’s skin and into a mass, to make sure it is going to the correct place.

Another method used for breast biopsy is stereotactic biopsy, which uses x-ray (or mammogram) guidance instead of ultrasound guidance.  Because x-rays cannot be done as real-time exams, in a stereotactic biopsy the physician (with the help of a computer program) figures out exactly where to place the needle based on x-rays taken prior to the biopsy.  After careful planning, a machine helps the physician place the needle in the center of the mass.  X-rays are taken again aftre the needle is placed, to confirm that it is in the correct position.

As we discussed in the last edition, a newer technique for breast biopsy is MRI-guided biopsy, which is used only for masses that cannot be seen on either a mammogram or ultrasound.

Breast-MRI

Radiology: The Basic Modalities
MRI Mammography – Vol. 1, Number 5

Wednesday, October 24th, 2007

How it works. Breast MRI is a test that uses a large magnet and a radio wave to differentiate the various tissues within the breast.  It does not expose the breast to any damaging radiation and detects cancers more accurately than mammography.  (We’ll go into more detail about magnetic resonance imaging in future issues.)

Given these facts, why doesn’t every woman get breast MRI for screening?  There are several reasons:

  • Breast MRI is much more expensive and takes much longer than conventional x-ray mammography. While a mammogram can be completed in less than 15 minutes, a breast MRI usually takes about an hour.
  • Because breast MRI is so sensitive, it often detects masses than are not cancerous, as does conventional mammography. This can lead to unnecessary biopsy – a procedure in which a needle is used to collect a piece of a mass to determine if it is cancerous.  One study showed that about 8% of women who get mammograms get biopsies.  Because of our readers’ experience, however, we have been able to decrease the biospy rate by 20% by using breast MRI.

How It’s Done
First, a set of MRI pictures of the breasts is taken.  Then a contrast agent is injected into the patient’s vein, and another set of pictures of the breasts is taken.  The first set of images is subtracted from the contrast-enhanced images, creating a set of pictures (“subtraction images”) that accentuate the areas that take up more of the contrast solution.

This helps the radiologist distinguish tumors from normal breast tissue, because contrast is carried to the tissue by blood vessels.  This means that the amount of contrast that appears in a tissue or tumor is dependent on its vascularity.  In a malignant tumor, the blood vessels are more numerous, more tortuous, and are dysplastic with leaky membranes.  For this reason, flow and perfusion to a cancer is higher than normal tissue, and the leakage of contrast into the cancer is faster.  This allows a radiologist to analyze the perfusion curve of a mass, to determine whether it is malignant.

INDICATIONS FOR BREAST MRI

  • Screening women at high risk for breast cancer (because of family history or genetic abnormality)
  • Screening women with a previous history of breast cancer
  • Looking for other sites of cancer in the same breast and other breast in women with known breast cancer
  • Monitoring cancer’s response to treatment
  • Clarifying indeterminate results of mammogram or ultrasound

RESEARCH USES OF BREAST MRI

  • Measurement of tumor angiogenesis (new vessel production)
  • Monitoring chemotherapy response
  • Tumor volume and multiplicity
  • Oxygen consumption of tumor
  • Diffusion characteristics of tumor
  • Tumor permeability for chemotherapy delivery
  • Tumor elasticity
  • Tumor chemistry (choline content)

Radiology: The Basic Modalities
Conventional Mammography – Vol. 1, Number 4

Wednesday, October 17th, 2007

How it works. A mammogram is  simply an x-ray image taken of each breast.  The breasts are compressed while the x-ray is taken, to increase the radiologist’s ability to see abnormal masses.  Mammograms expose the breasts to a relatively small amount of radiation, typically less than 20% of average yearly background radiation.

How the Images are Made
The x-rays used to create mammograms are essentially the same as the ones to make an x-ray of the chest or hand; dense structures (like fat) appear as black.  Low-energy x-rays are used to create mammograms, so that soft tissues (such as masses) are whiter and thus easier to see.  Calcifications are a bright white, soft tissues (breast glands and masses) are a softer white, and breast fat is black.

When we search for a tumor on a mammogram, we are looking for a soft-tissue mass, which will appear white.  This can be difficult to distinguish from normal glandular tissue, which also appears white – particularly in patients with “dense” breasts that contain a lot of glands (especially Asian, younger, or smaller-breasted women).

Mammographers use the characteristics of a mass to determine whether it looks benign or malignant, and they give it a rating on the BI-RADS (Breast Imaging Reporting and Data System) scale (see below).  An indirect sign of a malignant breast mass is a focal area of tiny calcifications, or microcalcifications, which the mammographer can see using magnifying glasses.

Bi-Rad-chart

MAMMOGRAPHY’S MOST COMMON USES

Screening Mammograms.  A mammogram is the standard screening test for breast cancer today.  A “screening” exam is a test used for routine check-ups, to make sure that presumably healthy people do not have a specific disease.  Other examples of screening tests are colonoscopies to evaluate for colon cancer, or yearly blood tests to evaluate men for prostate cancer.  These tests are performed on all people within a certain age group to evaluate for common diseases, so that they can be recognized and treated early.

Since breast cancer is relatively common, potentially deadly, and treatable, screening for this disease is very important.  A screening mammogram consists of two standard views: craniocaudal (CC), in which the breast is compressed from top to bottom, and mediolateral oblique (MLO), in which the breast is compressed from side to side.  Although mammograms often detect masses that are not cancerous and often miss small cancers, they are currently the best test that we have for screening women at low to average risk for cancer.

Diagnostic Mammograms. Once a mass is found on a screening mammogram, the patient will often return to have a diagnostic mammogram, which consists of specialized, close-up views of the mass with extra compression.  This will help the mammographer better characterize the mass as either benign or malignant.